Chronotoxicity of Sodium Valproate in Pregnant Mouse and Embryo
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Chronotoxicity of sodium valproate in pregnant mouse and embryo.
The influence of dosing time on the embryotoxicity of sodium valproate (valproic acid, VPA) was investigated in ICR mice under a light-dark (12:12) cycle. A significant circadian rhythm was shown for VPA-induced embryotoxicity, with the highest value at 1700 and the lowest at 0100. A similar pattern of rhythm was also shown for VPA-induced toxicity in pregnant and nonpregnant mice. No significa...
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Correspondence Sodium valproate and pregnancy Sir, We were presented with a baby born to a mother taking sodium valproate who wished to breast feed. There are no data on breast milk levels of sodium valproate; it is presumed from collateral evidence that some of the drug would pass across from maternal serum into the milk. Studies in animals given modest doses of sodium valproate during pregnan...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1996
ISSN: 0021-5198
DOI: 10.1254/jjp.70.253